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Scientists Report Explanation for Protein Clumps in Autopsy Brain Cells of ALS Patients

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Autopsies of nearly every patient with the lethal neurodegenerative disorder amyotrophic lateral sclerosis (ALS), and many with frontotemporal dementia (FTD), show pathologists telltale clumps of a protein called TDP-43. Now, working with mouse and human cells, Johns Hopkins researchers report they have discovered the normal role of TDP-43 in cells and why its abnormal accumulation […]

New Packard Study Provides New Understanding of TDP-43 in ALS

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Packard scientist Phil Wong and colleagues have published a new study in Science that outlines the normal function of the ALS-linked protein TDP-43 and spells out more clearly how loss of this function contributes to disease. Unlike other RNA-binding proteins, TDP-43 does not mainly control splicing of normal exons, but rather keeps potentially damaging ‘hidden’ […]

Ice Bucket Challenge: Jonathan Ling and Philip Wong

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Ice bucket challenge helped spur ALS discovery, scientists say

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Money raised from the Ice Bucket Challenge that went viral last year has significantly boosted research into ALS, scientists at Johns Hopkins say.   They say it has helped them to understand more about a dysfunctional protein – TDP-43 – a mystery scientists have been studying for decades. ALS is a rare condition affecting the […]

FINISH! Giants Coach Tom Coughlin presents Holland Reynolds with the AMND Hero for Hope Award!

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The NEW YORK GIANTS and their head coach Tom Coughlin sent this video to the AMND Organization to honor the efforts of Holland Reynolds for her role in crawling across the finish line at her scholastic state track championship meet to honor her coach Jim Tracy who had been diagnosed with the disease ALS. It […]

Jim Tracy’s Girls’ XC Win 10th State Title!

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The University girls cross-country team won the D5 California State Title for the 4th consecutive year this morning, earning Coach Jim Tracy a record 10 California State Championship titles in his 18 years as coach at San Francisco University High School. Remarkable!! http://blog.sfgate.com/prepsports/2012/11/24/university-girls-jim-tracy-take-record-10th-state-cross-country-title/

Running for Jim Reviews

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A powerful film about the will to finish. In my life, I have met and seen many inspirational people, but very few have had the ability to reach out and change the lives of others the way Jim Tracy has and continues to do. This film takes you into Jim’s life, his love of running […]